• image.alt
  • With Mayo Clinic psychiatrist

    Daniel K. Hall-Flavin, M.D.

    read biography

Mayo Clinic Health Manager

Get free personalized health guidance for you and your family.

Get Started

Free

E-Newsletters

Subscribe to receive the latest updates on health topics. About our newsletters

  • Housecall
  • Alzheimer's caregiving
  • Living with cancer

Question

Mild depression: Are antidepressants effective?

I've heard antidepressants don't work for mild depression. Is that true?

Answer

from Daniel K. Hall-Flavin, M.D.

Antidepressants don't work for everyone. For many people with mild depression, antidepressants seem to have little effect. However, for people with more severe depression, antidepressants often make a big difference.

Although antidepressants generally aren't as effective for mild depression, that doesn't mean that they never help. Depression affects each person differently, and each person responds to medications differently. If an antidepressant seems to ease your symptoms, it may be a good treatment choice for you. If you're taking an antidepressant for mild depression, don't stop taking it without talking to your doctor.

For many people, psychological counseling (psychotherapy) is just as effective as taking medications. Lifestyle changes — such as stress reduction and regular exercise — also can make a difference. Many people benefit most from a combination of treatments.

If you do have signs and symptoms of depression, don't ignore them. Even mild depression can take a toll on your enjoyment of life, your performance at work or school, and your relationships with other people. And, left untreated, depression can get worse. Explore your treatment options with your doctor or mental health provider to figure out what's likely to work best to help you feel better again.

Next question
Antidepressants: Can they stop working?
References
  1. Rief W, et al. Meta-analysis of the placebo response in antidepressant trials. Journal of Affective Disorders. 2009;118:1.
  2. Fournier JC, et al. Antidepressant drug effects and depression severity: A patient-level meta-analysis. Journal of the American Medical Association. 2010;303:47.
  3. Kirsch I, et al. Initial severity and antidepressant benefits: A meta-analysis of data submitted to the Food and Drug Administration. PLoS Medicine. 2008;5:e45. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.0050045. Accessed Feb. 1, 2010.

AN02074

April 23, 2010

© 1998-2010 Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. A single copy of these materials may be reprinted for noncommercial personal use only. "Mayo," "Mayo Clinic," "MayoClinic.com," "EmbodyHealth," "Enhance your life," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.

Print Share Reprints

Text Size: smaller largerlarger